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has been marketed for the treatment of amoebic dysentery.
The latest in scientific research shows Mangosteen contains a class of naturally occurring polyphenolic compounds known as xanthones. Xanthones provide beneficial effects on cardiovascular diseases, including ischemic heart disease, atherosclerosis, hypertension, and thrombosis. Xanthones demonstrate particularly powerful antioxidant properties.
Xanthones are found in a limited number of rain forest plants, but nowhere are they found in greater abundance than in the rind of the Mangosteen fruit.The medicinal properties of the Mangosteen fruit are derived mainly from its outer rind or peel, not from the fleshy inner part of the fruit. The rind, called the pericarp, is where powerful antioxidants are highly concentrated. The Mangosteen pericarp is about a half-centimeter thick and is green when unripe, then dark purple when ripe.
These unique antioxidants, known as Xanthones, have properties which help to heal cells damaged by free radicals, slow aging, and ward off degenerative diseases and physical and mental deterioration.
The rind of partially ripe Mangosteen fruit yields a polyhydroxy-xanthone derivative termed mangostin, also beta-mangostin. That of fully ripe fruits contains the xanthones gartanin, beta-disoxygartanin, and normangostin.
According to research reported in professional journals such as Free Radical Research and the Journal of Pharmacology, these amazing Xanthones have a remarkablly beneficial effect on cardiovascular health. They are also naturally antibiotic, antiviral, and anti-inflammatory. Xanthones are among the most powerful antioxidants to be found in nature.
Many of the other health benefits of Xanthones from Mangosteen pericarp can be expressed in terms of how they act against or are "anti" various serious ailments...
anti-fatigue, anti-obesity, anti-depression, anti-anxiety, anti-vertigo (dizziness), anti-Alzheimer’s, anti-Parkinsonism (Parkinson's Disease), anti-allergenic, anti-seborrheic (skin disease), anti-glaucoma (eye disease), anti-pyretic (anti-fever), anti-diarrhea, anti-periodontic (gum disease), anti-pain (such as dental pain), anti-neuralgia (nerve pain), anti-arthritis, anti-inflammatory (act as cox-2 inhibitors like the pharmaceutical drugs Vioxx(tm) and Celebrex(tm), but without the deadly side-effects), and anti-ulcer (such as ulcers of the stomach, mouth, small bowel, or large bowel).
Some of the Xanthones in the Mangosteen pericarp have powerful anti-inflammatory properties which may be of interest to those who suffer the pain of sciatica and peripheray neuropathy, which cannot be effectively controlled by drug treatments. The amount of Mangosteen consumed per day may need to be increased by two or three times to support pain relief through its anti-inflammatory and cox-2 inhibitor effects.
Mangosteen fruit also shows vasorelaxant properties (causing dilation of blood vessels and increased blood flow).
With Mycobacterium tuberculosis (TB) and Staphylococcus aureus (Staph. A) bacteria, Mangosteen has shown inhibitory action against these harmful bacteria organisms. In addition to its antibacterial properties, Mangosteen fruit also demonstrates strong antifungal properties. It is highly effective in boosting weak immune systems.
There are several compounds found in the Mangosteen that appear to make this fruit so active as a nutritional component for the body.
Research and References
NOTES: In the following citations of research studies, the medical term apoptosis refers to "cell death" after a cell has reproduced a certain number of times, then dies naturally (here, it refers to the death of cancer cells). Induction of apoptosis means "initiating apoptosis" of the cancer cells. HIV-1 refers to the AIDS virus. Low density lipoptrotein refers to "LDL cholesterol", the "bad cholesterol" that can form plaque in the arteries and increase the risk of heart disease or death by stroke or heart attack.
Jiang, D.J. e. al. Pharmacological effects of xanthones as cardiovascular protective agents. Cardiovascular Drug Reviews, 2004, 22(2):91-102
Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana on SKBR3 human breast cancer cell line. J. Ethnopharmacol, 2004 Jan:90(1):161-6
Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J. Nat Prod. 2003 Aug;55(8):1124-7
Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. J. Nat Prod 1997 May; 60 (5):519-24
Active constituents against HIV-1 protease from Mangosteen. Planta Med 1996 Aug;62(4):381-2
Mangostin inhibits the oxidative modification of human low density lipoprotein. Free radical Research. 1995 Aug.:23(2):175-84
There are several health juice drinks or functional beverages available over the Internet which contain Mangosteen fruit or the rind, or a concentrate of the Mangosteen fruit. With the exception of Acai Plus™, most of the health juice products on the market today contain 15 to 50 mg of Mangosteen fruit, Goji berry, or Acai berry per serving - but not all three.
We recommend a product called more healthy fruit concentrate at less cost than other top-selling health juice drinks with Mangosteen fruit, Acai berries, or Goji berries - such as Xango™, MonaVie™, Fruta Vida™, Vemma™, or Himalayan Goji™ Juice.
The AMiGO Juice is a dry powder product (also comes in capsule form) which contains real Mangosteen fruit pericarp (Garcinia mangostana) obtained from fruit that is freshly harvested in Thailand and freeze-dried, which removes the water content while preserving the nutrients.
This results in:
(1) lower shipping costs when you are not paying to ship the water or liquid juices from other fruits added to the product,
(2) greatly reduced chance of spoilage, and a longer shelf life, and
(3) more convenient storage of the dry powder, which need not be refrigerated and can be easily carried with you while away from home.
You can either add the AMiGO Juice concentrate powder to water, or to another fruit juice, or mix it into a "smoothie" shake - OR you can order the powdered extract in a vegetarian gel capsule and simply take two capsules with water.
The AMiGO Juice product sold by Amigo Health Sciences in Colorado, USA, contains 90 servings per 270-gram container of powder, or 90 servings from a bottle of 180 capsules. Suggested use is 3 servings per day, so with typical use it will provide a 30-day supply of 4.5 grams of juice concentrate per day for one person.
The AMiGO Juice products can be shipped to the USA, Canada, Mexico, and many overseas countries "for personal use".
AMiGO Juice is the natural "whole food" functional beverage with more healthy fruit concentrate at less cost than other top-selling health juice drinks with Mangosteen fruit, Acai berries, or Goji berries - such as Acai Plus™, MonaVie™, Fruta Vida™, Vemma™, Xango™, or Himalayan Goji™ Juice. Xango™, MonaVie™, Fruta Vida™, Vemma™, or Himalayan Goji™ Juice.
With this Acai Plus™, a liquid health juice, also contains Acai, Goji and Mangosteen fruit, plus 100 other healthy ingredients.)
Three servings of AMiGO Juice per day will deliver a total of 1.5 grams (1,500 milligrams) of dehydrated Thai Mangosteen fruit pericarp, 1.5 grams of dehydrated Himalayan Goji berry fruit, plus 1.5 grams of dehydrated Brazilian Acai berry - a total of 4.5 grams of these top three super-healthy fruits! This is much more of the actual Mangosteen fruit pericarp concentrate than most of the "Mangosteen" products actually deliver per serving or per daily dose, typically 5 to 50 milligrams per serving, compared to 500 milligrams of Mangosteen fruit pericarp per serving of AMiGO Juice.
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